Author

J. L. Keck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:bacteria (other)· 2 Assay:DNA methylation· 2 Organism:E. coli· 2 Assay:proteomics· 2 Approach:deep learning· 1

Frequent Co-Authors

R. R. Cueny· 2 shared A. F. Voter· 1 shared A. Gitter· 1 shared A. Hao· 1 shared A. J. Fernandez· 1 shared B. M. Burton· 1 shared B. W. Anderson· 1 shared E. A. Wood· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

R. R. Cueny

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Author profile →

6 papers

Recent·Most cited

Biochemical Properties of Naturally Occurring Human Bloom Helicase Variants

R. R. Cueny, S. Varma, K. H. Schmidt, J. L. Keck

This study characterizes the biochemical properties of naturally occurring BLM mutations, finding that P868L and G1120R retain helicase function but may contribute to genome instability, while K869A K870A shows reduced ATPase and helicase activity.

bioRxiv · Jan 26, 2023 · PreprintBiochemistry

Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities

M. A. O. Garcia, E. A. Wood, J. L. Keck, M. M. Cox

The paper investigates how RadD interacts with SSB to modulate its ATPase activity and DNA repair functions in E. coli.

bioRxiv · Dec 5, 2022 · PreprintBiochemistry

Natural transformation protein ComFA exhibits single-stranded DNA translocase activity

H. R. Foster, X. Lin, S. Srikant, R. R. Cueny, T. G. Falbel, J. L. Keck, R. Gaudet, B. M. Burton

This study investigates ComFA's role in natural transformation by demonstrating its single-stranded DNA translocase activity and ATP-dependent DNA release mechanism.

bioRxiv · Oct 29, 2021Microbiology

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

N. Puri, A. J. Fernandez, V. L. O'Shea Murray, S. McMillan, J. L. Keck, J. M. Berger

This study investigates how ATPase elements in E. coli DnaC regulate helicase loading and DNA unwinding, identifying a new element called the arginine-coupler that prevents futile ATP cycling.

bioRxiv · Oct 21, 2020Biochemistry

Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp

B. W. Anderson, A. Hao, K. A. Satyshur, J. L. Keck, J. D. Wang

This study identifies how alarmones pppGpp, ppGpp, and pGpp inhibit XPRT activity by competing with PRPP, revealing structural and regulatory differences between XPRT and HPRT.

bioRxiv · Mar 4, 2020Microbiology

Practical model selection for prospective virtual screening

S. Liu, M. Alnammi, S. S. Ericksen, A. F. Voter, G. E. Ananiev, J. L. Keck, F. M. Hoffmann, S. A. Wildman, A. Gitter

The paper evaluates virtual screening algorithms for two protein-protein interactions and finds random forest outperforms neural networks in prospective compound prioritization.

bioRxiv · Sep 15, 2018Biochemistry