TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
A. J. Guise, S. A. Misal, R. Carson, H. Boekweg, D. Van Der Watt, T. Truong, Y. Liang, J.-H. Chu, N. Welsh, J. Gagnon, S. H. Payne, E. D. Plowey, R. T. Kelly
This study uses single-cell proteomics to analyze motor neurons from ALS patients, identifying protein changes linked to TDP-43 pathology.
bioRxiv · Jun 8, 2023Pathology