Author

R. T. Kelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:deep learning· 2 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Y. Liang· 3 shared H. Boekweg· 2 shared S. H. Payne· 2 shared T. Truong· 2 shared A. J. Guise· 1 shared A. Nydegger· 1 shared C. Lundgren· 1 shared D. C. Ellwanger· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Y. Liang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated Ion-Tandem Mass Tags (AI-TMT)

T. Peters-Clarke, Y. Liang, K. L. Mertz, K. W. Lee, M. S. Westphall, J. D. Hinkle, G. C. McAlister, J. E. P. Syka, R. T. Kelly, J. Coon

This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.

bioRxiv · Feb 24, 2024 · PreprintBiochemistry

TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

A. J. Guise, S. A. Misal, R. Carson, H. Boekweg, D. Van Der Watt, T. Truong, Y. Liang, J.-H. Chu, N. Welsh, J. Gagnon, S. H. Payne, E. D. Plowey, R. T. Kelly

This study uses single-cell proteomics to analyze motor neurons from ALS patients, identifying protein changes linked to TDP-43 pathology.

bioRxiv · Jun 8, 2023Pathology

Data-Dependent Acquisition with Precursor Coisolation Improves Proteome Coverage and Measurement Throughput for Label-Free Single-Cell Proteomics

T. Truong, S. M. Johnston, K. Webber, H. Boekweg, C. Lundgren, Y. Liang, A. Nydegger, X. Xie, S. H. Payne, R. T. Kelly

This paper introduces WWA, a data acquisition method that improves proteome coverage and throughput in single-cell proteomics by co-isolating and fragmenting additional precursors.

bioRxiv · Oct 18, 2022Cell Biology

Single-cell proteomics reveals downregulation of TMSB4X to drive actin release for stereocilia assembly

Y. Zhu, M. Scheibinger, D. C. Ellwanger, J. F. Krey, D. Choi, R. T. Kelly, S. Heller, P. G. Barr-Gillespie

The paper uses single-cell proteomics to show TMSB4X downregulation drives actin release for stereocilia assembly in hair cells.

bioRxiv · Aug 6, 2019 · PreprintCell Biology