S. H. Payne

TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

This study uses single-cell proteomics to analyze motor neurons from ALS patients, identifying protein changes linked to TDP-43 pathology.

Data-Dependent Acquisition with Precursor Coisolation Improves Proteome Coverage and Measurement Throughput for Label-Free Single-Cell Proteomics

This paper introduces WWA, a data acquisition method that improves proteome coverage and throughput in single-cell proteomics by co-isolating and fragmenting additional precursors.

Meta-analysis refinement of plasma extracellular vesicle composition identifies proplatelet basic protein as a signaling messenger in type 1 diabetes

A Histoplasma capsulatum lipid metabolic map identifies antifungal targets

This study constructs a lipid metabolic map of Histoplasma capsulatum and identifies potential antifungal drug targets through pathway validation and compound testing.

Bacterial longevity requires protein synthesis and a stringent response

This study shows that protein synthesis and a stringent response are required for bacterial longevity during growth arrest in Rhodopseudomonas palustris.

Identification of novel protein lysine acetyltransferasesin Escherichia coli

This study identifies four new Nε-lysine acetyltransferases in E. coli and shows they have distinct substrate specificity and regulatory roles in bacterial motility.