T. Truong

TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

This study uses single-cell proteomics to analyze motor neurons from ALS patients, identifying protein changes linked to TDP-43 pathology.

Data-Dependent Acquisition with Precursor Coisolation Improves Proteome Coverage and Measurement Throughput for Label-Free Single-Cell Proteomics

This paper introduces WWA, a data acquisition method that improves proteome coverage and throughput in single-cell proteomics by co-isolating and fragmenting additional precursors.

Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells

The paper demonstrates that latency reversal enhances the toxicity of HIV protease-activated toxins, preferentially eliminating HIV-infected cells in mixed populations.

Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza Virus

This study develops and tests a bivalent rVSV vaccine targeting SARS-CoV-2 Delta and influenza, showing strong immune responses and protection in animal models.

Notch Intracellular Domain Plasmid Delivery via Poly(lactic-co-glycolic acid)Nanoparticles to Upregulate Notch Signaling

This study delivers Notch Intracellular Domain plasmid via PLGA nanoparticles to upregulate Notch signaling in HUVECs, showing nontoxicity, stability, and successful gene expression.

The role of advective transport mechanism in continental-scale transport of fungal plant epidemics

The paper argues that free tropospheric advection, despite low spore survival rates, is a crucial mechanism for continental-scale spread of fungal plant epidemics.