Author

A. J. O'Donnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Ecology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. F. Prior· 6 shared S. E. Reece· 6 shared D. R. van der Veen· 2 shared N. J. Savill· 2 shared S. S. Rund· 2 shared A. Pain· 1 shared A. Ramaprasad· 1 shared A. Subudhi· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersMicrobiology

K. F. Prior

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Consequences of daily rhythm disruption on host-parasite malaria infection dynamics

J. G. Holland, K. F. Prior, A. J. O'Donnell, S. E. Reece

This study investigates how disrupting host daily rhythms affects malaria parasite infection dynamics, finding that feeding-fasting rhythms may benefit parasites when hosts have functional circadian clocks.

bioRxiv · Aug 24, 2023 · PreprintEvolutionary Biology

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

K. F. Prior, B. Middleton, A. T. Owolabi, M. L. Westwood, J. Holland, A. J. O'Donnell, M. J. Blackman, D. J. Skene, S. E. Reece

This study shows malaria parasites synchronize their asexual replication with host daily rhythms via the essential amino acid isoleucine, which is periodically supplied through host feeding.

bioRxiv · Aug 24, 2020 · PreprintMicrobiology

Host circadian clocks do not set the schedule for the within-host replication of malaria parasites

A. J. O'Donnell, K. F. Prior, S. E. Reece

The paper shows malaria parasites synchronize their replication with host feeding times, independent of host circadian clocks, suggesting nutrient availability or feeding-related processes drive this coordination.

bioRxiv · Sep 25, 2019Ecology

Host circadian rhythms are disrupted during malaria infection in parasite genotype-specific manners

K. F. Prior, A. J. O'Donnell, S. S. Rund, N. J. Savill, D. R. van der Veen, S. E. Reece

This study shows that malaria parasite genotypes differentially disrupt host circadian rhythms in locomotor activity and body temperature, independent of replication rate or anaemia severity.

bioRxiv · Jun 13, 2019Ecology

Adaptive periodicity in the infectivity of malaria gametocytes to mosquitoes

P. Schneider, S. S. C. Rund, N. L. Smith, K. F. Prior, A. J. O'Donnell, S. E. Reece

The paper shows that malaria gametocytes are more infective to mosquitoes at night, despite lower blood density, and that daytime feeding increases sporozoite burdens due to higher mosquito susceptibility.

bioRxiv · Apr 5, 2018Microbiology

Timing of host feeding drives rhythms in parasite replication

K. F. Prior, D. R. van der Veen, A. J. O'Donnell, K. Cumnock, D. Schneider, A. Pain, A. Subudhi, A. Ramaprasad, S. S. Rund, N. J. Savill, S. E. Reece

This study shows that host feeding rhythms, not central circadian clocks, drive parasite replication timing in malaria, with parasite rhythms aligning to host glucose rhythms and not immune system rhythms.

bioRxiv · Dec 6, 2017Microbiology