Author

A. Ramaprasad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Pain· 3 shared P.-C. Burda· 3 shared A. Sait· 2 shared E. Calvani· 2 shared E. Pietsch· 2 shared J. I. MacRae· 2 shared M. Blackman· 2 shared M. J. Blackman· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

A. Pain

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Author profile →

7 papers

Recent·Most cited

A scaleable inducible knockout systemfor studying essential gene function inthe malaria parasite

A. Ramaprasad, M. Blackman

The paper develops SHIFTiKO, a scalable inducible knockout system for studying essential gene function in malaria parasites, demonstrating its use in identifying blood stage-specific essentiality of rhomboid proteases.

bioRxiv · Jan 14, 2024Microbiology

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

A. Ramaprasad, P.-C. Burda, K. Koussis, J. A. Thomas, E. Pietsch, E. Calvani, S. A. Howell, J. I. MacRae, A. P. Snijders, T. W. Gilberger, M. J. Blackman

This study identifies LCAT as a key enzyme required for efficient egress of malaria parasites from red blood cells during the asexual blood stage.

bioRxiv · Mar 13, 2023Microbiology

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

A. Ramaprasad, P.-C. Burda, E. Calvani, A. Sait, S. A. Palma-Duran, C. Withers-Martinez, F. Hackett, J. I. MacRae, L. Collinson, T. Gilberger, M. Blackman

This study identifies PfGDPD as a choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in Plasmodium falciparum.

bioRxiv · Jun 14, 2022Microbiology

Global analysis of putative phospholipases in the malaria parasite Plasmodium falciparum reveals critical factors for parasite proliferation

P.-C. Burda, A. Ramaprasad, E. Pietsch, S. Bielfeld, C. Söhnchen, L. Wilcke, J. Strauss, D. Schwudke, A. Sait, L. M. Collinson, M. J. Blackman, T.-W. Gilberger

The paper identifies essential phospholipases in Plasmodium falciparum, showing PF3D7_1013500 is critical for parasite maturation and PF3D7_1358000 is vital for mitochondrial function and growth.

bioRxiv · Jun 28, 2021 · PreprintMicrobiology

MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

D. Guttery, A. Ramaprasad, D. Ferguson, M. Zeeshan, R. Pandey, D. Brady, A. A. Holder, A. Pain, R. Tewari

This study shows that MRE11 is essential for Plasmodium development in mosquitoes, with its absence causing transcriptional changes in critical biological processes and blocking parasite transmission.

bioRxiv · Aug 24, 2020Cell Biology

A fast and cost-effective microsampling protocol incorporating reduced animal usage for time-series transcriptomics in rodent malaria parasites

A. Ramaprasad, A. K. Subudhi, R. Culleton, A. Pain

This study develops a microsampling protocol for rodent malaria parasites that reduces animal usage and enables time-series transcriptomics with high correlation to traditional methods.

bioRxiv · Jun 20, 2018Microbiology

Timing of host feeding drives rhythms in parasite replication

K. F. Prior, D. R. van der Veen, A. J. O'Donnell, K. Cumnock, D. Schneider, A. Pain, A. Subudhi, A. Ramaprasad, S. S. Rund, N. J. Savill, S. E. Reece

This study shows that host feeding rhythms, not central circadian clocks, drive parasite replication timing in malaria, with parasite rhythms aligning to host glucose rhythms and not immune system rhythms.

bioRxiv · Dec 6, 2017Microbiology