Author

A. J. Pfeil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. F. Coleman· 2 shared S. D. Hursting· 2 shared A. A. Fodor· 1 shared A. G. Lewis· 1 shared D. Teegarden· 1 shared E. K. Cotul· 1 shared E. M. Glenny· 1 shared E. N. Devericks· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

M. F. Coleman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Calorie Restriction Outperforms Bariatric Surgery in a Murine Model of Obesity and Triple-Negative Breast Cancer

M. F. Coleman, K. K. Camp, T. L. McFarlane, S. S. Doerstling, S. A. Khatib, E. T. Rezeli, A. G. Lewis, A. J. Pfeil, L. A. Smith, F. Fouladi, W. Gong, E. M. Glenny, J. S. Parker, G. L. Milne, I. M. Carroll, , S. D. Hursting

This study compares the effects of bariatric surgery and calorie restriction on obesity-driven triple-negative breast cancer in mice, finding calorie restriction more effective in reversing tumor growth.

bioRxiv · May 19, 2023 · PreprintCancer Biology

Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression

M. F. Coleman, E. K. Cotul, A. J. Pfeil, E. N. Devericks, H. Chen, V. A. Kiesel, M. Safdar, D. Teegarden, S. D. Hursting, M. K. Wendt

This study shows that hypoxia suppresses pyruvate carboxylase (PC) in tumors, leading to increased lactate production and immunosuppression in the tumor microenvironment.

bioRxiv · Apr 6, 2022 · PreprintCancer Biology