Author

V. A. Kiesel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

M. F. Coleman· 2 shared S. D. Hursting· 2 shared A. J. Pfeil· 1 shared A. L. Kucinskas· 1 shared A. N. Ho· 1 shared B. P. Riesenberg· 1 shared C. A. Holt· 1 shared C. E. Gates· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

M. F. Coleman

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2 papers

Recent·Most cited

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

E. M. Glenny, M. F. Coleman, G. T. Clutton, B. P. Riesenberg, A. N. Ho, T. L. McFarlane, V. A. Kiesel, A. L. Kucinskas, E. G. Bailey, K. E. Sanchez, J. Zeng, Y. Wang, H. M. Malian, C. E. Gates, F. Chen, , S. D. Hursting

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

bioRxiv · Jan 20, 2024 · PreprintCancer Biology

Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression

M. F. Coleman, E. K. Cotul, A. J. Pfeil, E. N. Devericks, H. Chen, V. A. Kiesel, M. Safdar, D. Teegarden, S. D. Hursting, M. K. Wendt

This study shows that hypoxia suppresses pyruvate carboxylase (PC) in tumors, leading to increased lactate production and immunosuppression in the tumor microenvironment.

bioRxiv · Apr 6, 2022 · PreprintCancer Biology