W. Gong

Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1

This study presents cryo-EM structures of MCHR1 in active and inactive states, revealing ligand recognition and activation mechanisms to aid drug development.

The kinematics and aerodynamics of hinged wing of honeybees during takeoff

This study analyzes honeybee wing kinematics during takeoff, revealing key parameters and the role of hinged wings in thrust generation.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

Elf1 promotes Rad26 interaction with lesion-arrested Pol II for transcription-coupled repair

The paper investigates how Rad26 interacts with lesion-arrested Pol II and identifies Elf1's role in enhancing this interaction for transcription-coupled repair.

Structure and evolution of Alanine/Serine Decarboxylases and the engineering of theanine production

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

Multi-color live-cell optical nanoscopy using phasor analysis

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Calorie Restriction Outperforms Bariatric Surgery in a Murine Model of Obesity and Triple-Negative Breast Cancer

This study compares the effects of bariatric surgery and calorie restriction on obesity-driven triple-negative breast cancer in mice, finding calorie restriction more effective in reversing tumor growth.

Quantitative analysis of food web dynamics in a low export ecosystem

The paper quantifies food web dynamics in a low export ecosystem, finding microbial recycling dominates carbon flow with minimal export due to slow turnover and high detrital background.

Angiopoietin-like 4 promotes the proliferation and migration of epidermal stem cells and contributes to the re-epithelialization of cutaneous wounds

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

Synechococcus nitrogen gene loss in iron-limited ocean regions

This study identifies two Synechococcus genomes from an iron-limited region that lack nitrate and nitrite assimilation genes, suggesting reliance on recycled nitrogen forms.

Novel Murine models of Mania and Depression

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

This study identifies ELOF1 as a factor that promotes transcription-coupled repair and prevents genome instability by modulating transcription and recruiting repair factors.

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells

The paper investigates how membrane protein aggregation and immobilization affect lipid order in T cells, revealing lipid-mediated recruitment of signaling proteins like Lck.

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

Requirement of the antimicrobial peptide CRAMP for macrophages to eliminate phagocytosed E. coli through an autophagy pathway

This study shows CRAMP is required for macrophages to eliminate phagocytosed E. coli via autophagy, involving ATG5, LC3-II, and LAMP-1.

CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition

This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.

SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

Genome-wide quantitative trait loci mapping on Verticilliumw

This study identifies 53 QTLs associated with Verticillium wilt resistance in cotton using CSSLs and detects 32 novel QTL hotspot regions, providing a foundation for genetic analysis and breeding programs.