A. J. R. Plested

State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca2+ activating mechanisms of the BK channel

The paper uses photocrosslinking to identify intersubunit interfaces in BK channels critical for Ca2+ activation.

Asymmetry and ion selectivity properties of bacterial channel NaK mutants mimicking ionotropic glutamate receptors

The paper determines high-resolution X-ray structures of NaK mutants mimicking AMPA receptor selectivity filters and reveals their ion selectivity and structural asymmetry through MD simulations and electrophysiology.

CaMKII activity spreads by inter-holoenzyme phosphorylation

This study identifies inter-holoenzyme phosphorylation as the mechanism for spreading CaMKII activity, challenging the subunit exchange hypothesis.

Non-selective cation permeation in an AMPA-type glutamate receptor

This paper investigates ion permeation mechanisms in AMPA-type glutamate receptors using molecular dynamics simulations and electrophysiology, finding a simple selectivity filter that allows non-selective cation permeation.

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

This study shows that Stargazin restricts conformational flexibility of AMPA receptors, preventing them from adopting relaxed states during brief glutamate exposure.

Control Of AMPA Receptor Activity By The Extracellular Loops Of Auxiliary Proteins

The paper investigates how extracellular loops of TARPs modulate AMPA receptor activity through structural models and functional assays, revealing key interactions and their impact on receptor kinetics.