Author

T. Giraldez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

M. Holmgren· 2 shared A. J. Gonzalez-Hernandez· 1 shared A. J. R. Plested· 1 shared B. Rivero-Perez· 1 shared D. Alvarez de la Rosa· 1 shared D. Bartolome-Martin· 1 shared J. Zhu· 1 shared N. de Val· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

M. Holmgren

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Author profile →

3 papers

Recent·Most cited

State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca2+ activating mechanisms of the BK channel

A. J. Gonzalez-Hernandez, B. Rivero-Perez, D. Bartolome-Martin, D. Alvarez de la Rosa, A. J. R. Plested, T. Giraldez

The paper uses photocrosslinking to identify intersubunit interfaces in BK channels critical for Ca2+ activation.

bioRxiv · Dec 15, 2022 · PreprintBiophysics

Structural bases for blockade and activation of BK channels by Ba2+ ions

S. Srivastava, P. Miranda Fernandez, N. de Val, T. Giraldez, J. Zhu, R. E. Cachau, M. Holmgren

The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.

bioRxiv · Jun 10, 2022Biophysics

The BK channel gating ring is strongly coupled to the voltage sensor

P. Miranda, M. Holmgren, T. Giraldez

This study shows that the BK channel's gating ring is tightly coupled to the voltage sensor, with conformational changes in the RCK1 domain responding to voltage shifts.

bioRxiv · Jul 31, 2018Biophysics