The kallikrein-kinin system is falling into pieces: bradykinin fragments are biological active peptides
I. M. Souza-Silva, C. A. de Paula, A. K. Santos, V. L. S. Oliveira, I. D. Rocha, M. Antunes, L. P. B. Cordeiro, V. P. Teixeira, S. Scalzo, F. A. Amaral, J. M. Resende, M. A. P. Fontes, G. B. Menezes, S. Guatimosim, R. Santos, T. Verano-Braga
This study investigates the biological activity of bradykinin fragments and finds they induce nitric oxide production and vasorelaxation independently of classical kinin receptors.
bioRxiv · Sep 14, 2020 · PreprintPharmacology & Toxicology