Author

A. Karasik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Koutmos· 3 shared C. A. Fierke· 2 shared C. Fierke· 1 shared K. Kaitany· 1 shared N. Wu· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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3 shared papersBiochemistry

M. Koutmos

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3 papers

Recent·Most cited

Mode of inhibition of RNase P by gambogic acid and juglone

N. Wu, A. Karasik, K. Kaitany, M. Koutmos, C. A. Fierke

This study identifies gambogic acid and juglone as inhibitors of PRORP1, with distinct mechanisms of action, and shows they also inhibit human mtRNase P.

bioRxiv · Oct 20, 2022 · PreprintBiochemistry

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P

A. Karasik, C. A. Fierke, M. Koutmos

This study examines how disease-linked mutations in mitochondrial pre-tRNAs affect mtRNase P activity, revealing a link between tRNA processing defects and mitochondrial disease.

RNA · Dec 30, 2020Peer-reviewedBiochemistry

Interplay between substrate recognition, 5’ end tRNA processing and methylation activity of human mitochondrial RNase P

A. Karasik, C. Fierke, M. Koutmos

This study shows that mtRNase P subunits synergistically recognize, cleave, and methylate some mitochondrial pre-tRNAs, with MRPP1/2 methylation activity enhanced by MRPP3.

bioRxiv · Oct 25, 2018Biochemistry