Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair
K. IWASAKI, H. KOBAYASHI, Y. Kamimura, Y. Horikoshi, A. Fukuto, J. Sun, M. Yasui, M. HONMA, A. Okabe, R. Fujiki, A. Keneda, S. Tashiro, A. Sassa, K. URA
This study shows NSD2 has dose-dependent effects on DSB repair pathways, repressing non-c-NHEJ and promoting c-NHEJ while not affecting HR or total NHEJ efficiency.
bioRxiv · Oct 18, 2023Cell Biology