K. Iwasaki

Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair

This study shows NSD2 has dose-dependent effects on DSB repair pathways, repressing non-c-NHEJ and promoting c-NHEJ while not affecting HR or total NHEJ efficiency.

Three-dimensional motions of GroEL during substrate protein recognition

The paper uses cryo-EM to study the 3D motions of GroEL during substrate recognition, revealing asymmetric binding and conformational dynamics at near-atomic resolution.

The role of geology in creating stream climate-change refugia along climate gradients

This study identifies how volcanic rock-dominated watersheds create cold water refugia in mountain streams, which are more resilient to climate change than non-volcanic streams.

LabGym: quantification of user-defined animal behaviors using learning-based holistic assessment

LabGym quantifies user-defined animal behaviors using a learning-based approach, providing holistic assessment without pre-defined features or species restrictions.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

Atomic structure of human sapovirus capsid by single particle cryo-electron microscopy

The paper reports the atomic structure of human sapovirus capsid using cryo-EM, revealing domain interactions and hypervariable regions important for immune response and receptor binding.

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.

Degradation of white birch shelterbelts by attack of white-spotted longicorn beetle in central Hokkaido, northern Japan.

The paper assesses the impact of white-spotted longicorn beetle infestation on white birch trees in central Hokkaido, finding a correlation between exit hole numbers and tree degradation.

Dynamic rotation of the protruding domain enhances the infectivity of norovirus

This study shows that the protruding domain of norovirus capsids dynamically rotates between rising and resting conformations in response to pH and metal ions, enhancing infection efficiency.

Translocational unfolding in clostridial binary iota toxin complex

This study reports the structure of the clostridial binary toxin translocation channel and its complex with ADP-ribosyltransferase, revealing a novel mechanism of N-terminal unfolding for protein translocation.