M. Yasui

DNA-free and genotype-independent CRISPR/Cas9 system in soybean

This paper develops a DNA-free CRISPR/Cas9 system in soybean using iPB-RNP method, achieving genome editing in shoot apical meristems without tissue culture, resulting in 0.4-4.6% mutation transmission to next generation.

Single-molecule tracking-based drug screening

This study uses single-molecule tracking to screen FDA-approved drugs for effects on EGFR mobility and clustering, identifying both known and novel compounds that impact EGFR function.

Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair

This study shows NSD2 has dose-dependent effects on DSB repair pathways, repressing non-c-NHEJ and promoting c-NHEJ while not affecting HR or total NHEJ efficiency.

Distribution of intraperitoneally administered D2O in AQP4-knockout mouse brain after MCA occlusion

This study uses D2O and MRI to assess how AQP4 loss affects water dynamics in the brain after focal ischemia, finding delayed signal changes in AQP4-knockout mice.

Quantitative Measurement of Diffusion-weighted Imaging Signal Using Expression-controlled Aquaporin-4 Cells: Comparative Study of 2-compartment and Diffusion Kurtosis Imaging Models

This study compares 2-compartment and diffusion kurtosis imaging models to assess how AQP4 expression affects diffusion-weighted imaging signal parameters in cell suspensions.