Y. Suenaga

Liver-specific LXR inhibition represses reverse cholesterol transport in cholesterol-fed mice

This study shows that liver-specific LXR inhibition reduces HDL levels and reverse cholesterol transport in cholesterol-fed mice by decreasing LXR-target gene expression.

The placental protein NRK promotes cell death through its plasma membrane-localizing CNH domain

This study identifies the CNH domain of NRK as a key mediator of cell death by localizing to the plasma membrane via phospholipid binding.

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

Protein-coding potential of RNAs measured by potentially translated island scores

This study introduces a PTI score to measure RNA coding potential and finds it correlates with translation and overlaps between coding and noncoding RNAs in different species.