Drug-bound and -free outward-facing structures of a multidrug ABC exporter point to a swing mechanism
v. Chaptal, V. Zampieri, B. Wiseman, C. Orelle, J. Martin, K.-A. Nguyen, S. Magnard, A. Gobet, M. Di cesare, W. Javed, A. Kilburg, M. Peuchmaur, J. Marcoux, M. Hogbom, J.-M. Jault, , P. G. Falson
The paper resolves two ATP-Mg2+-bound outward-facing conformations of BmrA, revealing a swing mechanism for drug transport through structural and dynamic analyses.
bioRxiv · Mar 12, 2021 · PreprintBiochemistry