Author

A. Klimas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 4 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:electrophysiology· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

E. Entcheva· 5 shared C. M. Ambrosi· 2 shared A. Kumar· 1 shared A. R. Sharkey· 1 shared B. Gallagher· 1 shared B. Rodriguez· 1 shared D. J. Paterson· 1 shared D. Li· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBioengineering

E. Entcheva

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy

L. Shi, A. Klimas, B. Gallagher, Z. Cheng, F. Fu, P. Wijesekara, Y. Miao, X. Ren, Y. Zhao, W. Min

The paper introduces MAGNIFIERS, a technique combining SRS microscopy with expansion microscopy to achieve sub-50 nm resolution and scalable multiplexity for label-free chemical imaging.

Advanced Science · May 6, 2022Peer-reviewedBioengineering

All-optical electrophysiology refines populations of in silico human iPS-CMs for drug evaluation

M. Paci, E. Passini, A. Klimas, S. Severi, J. Hyttinen, B. Rodriguez, E. Entcheva

This paper combines all-optical electrophysiology with in silico models to refine human hiPS-CMs for drug evaluation, showing accurate prediction of drug effects and adverse events.

bioRxiv · Oct 9, 2019Pharmacology & Toxicology

Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics

R. A. B. Burton, J. Tomek, C. M. Ambrosi, H. E. Larsen, A. R. Sharkey, R. A. Capel, S. Bilton, A. Klimas, G. Stephens, D. Li, G. Gallone, N. Herring, E. Mann, A. Kumar, H. Kramer, , G. Bub

This study uses optical methods to investigate how sympathetic neurons affect cardiac monolayer dynamics, focusing on neurotransmitter release, neuronal density effects, and optogenetics applications.

bioRxiv · Jul 30, 2019Biophysics

Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes

A. Klimas, G. Ortiz, S. Boggess, E. W. Miller, E. Entcheva

The paper introduces an all-optical platform for high-throughput electrophysiology in human stem-cell-derived cardiomyocytes using optogenetic stimulation and optical imaging.

bioRxiv · Feb 21, 2018Bioengineering

Adeno-associated virus mediated gene delivery: Implications for scalable in vitro and in vivo cardiac optogenetic models

C. M. Ambrosi, G. Sadananda, A. Klimas, E. Entcheva

This study compares AAV serotypes 1, 6, and 9 for cardiac optogenetic applications, finding AAV1/6 are more effective in vitro while AAV9 is superior in vivo due to receptor differences.

bioRxiv · Aug 31, 2017Bioengineering

OptoGap: an optogenetics-enabled assay for quantification of cell-cell coupling in multicellular cardiac tissue

J. Yu, P. M. Boyle, A. Klimas, J. C. Williams, N. A. Trayanova, E. Entcheva

The paper introduces OptoGap, a method to quantify cell-cell coupling in cardiac tissue by optogenetically stimulating nonexcitable cells and measuring the response in coupled excitable cells.

bioRxiv · Aug 2, 2017Bioengineering