J. C. Williams

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect

This study investigates how electrode placement on the pig vagus nerve affects therapeutic and side effects of vagus nerve stimulation.

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

Integrated cytometry with machine learning applied to high-content imaging of human kidney tissue for in-situ cell classification and neighborhood analysis

The paper introduces VTEA, a software tool that integrates machine learning and cytometry analysis for high-content imaging of human kidney tissue to classify cells and analyze their spatial neighborhoods.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

The Histoplasma capsulatum DDR48 Gene Is Required For Survival Within Macrophages, Response To Oxidative Stress, And Resistance to Antifungal Drugs

This paper identifies HcDDR48 as essential for Histoplasma capsulatum survival in macrophages, oxidative stress response, and antifungal drug resistance.

A Truly Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite

The paper introduces an injectable neural stimulation electrode made from a polymer/metal composite that conforms to neural structures and performs similarly to traditional electrodes in rats and swine.

Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules

This paper uses NMR spectroscopy to study the conformational flexibility of the p150Glued N-terminal region when bound to microtubules, revealing disordered regions and structural elements involved in microtubule binding.

OptoGap: an optogenetics-enabled assay for quantification of cell-cell coupling in multicellular cardiac tissue

The paper introduces OptoGap, a method to quantify cell-cell coupling in cardiac tissue by optogenetically stimulating nonexcitable cells and measuring the response in coupled excitable cells.