Molecular interaction mechanism of a 14-3-3 protein with a phosphorylated peptide elucidated by enhanced conformational sampling
J. Higo, T. Kawabata, A. Kusaka, K. Kasahara, N. Kamiya, I. Fukuda, K. Mori, Y. Hata, Y. Fukunishi, H. Nakamura
This paper uses enhanced conformational sampling to study the binding mechanism of a phosphorylated peptide to a 14-3-3 protein, identifying stable clusters and a phosphorylation-dependent binding process.
bioRxiv · May 24, 2020Biophysics