H. Nakamura

Identification of small molecule inhibitors of G3BP-driven stress granule formation

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

A severe bottleneck impacted the genomic structure of egg-eating cichlids

This study investigates the demographic history of egg-eating cichlids in Lake Victoria, finding a severe bottleneck in one species linked to the introduction of Nile perch.

Rapid Speciation Characterized by Incomplete Lineage Sorting in the Globally Distributed Bacterium Sulfitobacter

The paper identifies incomplete lineage sorting in Sulfitobacter, a marine bacterium, showing rapid speciation driven by ancestral polymorphism retention rather than adaptive selection.

Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule

This paper uses a computational method to simulate the binding mechanism of bosentan to hETB, identifying key steps like fly-casting and ligand-sliding.

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

In vivo study on the healing of bone defect treated with non-thermal atmospheric pressure gas discharge plasma

This study investigates the effect of non-thermal atmospheric pressure gas discharge plasma on bone regeneration in rabbits, finding that 10 minutes of treatment significantly increased new bone volume compared to controls.

Cluster Analysis of SARS-CoV-2 Gene using Deep Learning Autoencoder: Gene Profiling for Mutations and Transitions

The paper uses a deep learning autoencoder to analyze SARS-CoV-2 ORF1ab gene sequences, identifying five major types and tracking their temporal and geographic dynamics.

Molecular interaction mechanism of a 14-3-3 protein with a phosphorylated peptide elucidated by enhanced conformational sampling

This paper uses enhanced conformational sampling to study the binding mechanism of a phosphorylated peptide to a 14-3-3 protein, identifying stable clusters and a phosphorylation-dependent binding process.

Hair follicle stem cell progeny heal blisters while pausing skin development

The paper shows that skin blisters heal by sacrificing developmental programs, with HF stem cell progeny repairing wounds without promoting hair follicle growth.

ActuAtor, a molecular tool for generating force in living cells: Controlled deformation of intracellular structures

The paper introduces ActuAtor, a molecular tool that generates intracellular force by inducing actin polymerization, leading to deformation of various subcellular structures.

Rational design and implementation of a chemically inducible hetero-trimerization system

This paper designs a chemically inducible trimerization system by splitting FRB and FKBP, enabling precise control of tri-organellar junctions and membrane lipid perturbations in live cells.

Hydrogen Bond Donors and Acceptors are Generally Depolarized in α-Helices as Revealed by a Molecular Tailoring Approach

The paper examines H-bond interaction energies in α-helices using DFT calculations and a molecular tailoring approach, finding weaker energies due to depolarization effects.

Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy

This study shows that galectin-3 and N-acetylglucosamine enhance myogenesis and improve muscle function in the mdx DMD mouse model.