The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study
A. L. Ball, C. E. Jolly, J. Lyon, A. Alfirevic, A. Chadwick
This study generates HepG2 transmitochondrial cybrids with mtDNA haplogroups H and J to assess their susceptibility to mitochondrial toxicants, finding haplogroup J shows greater sensitivity to certain drugs.
eLife · Jun 6, 2023Peer-reviewedPharmacology & Toxicology