Author

J. Lyon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Bautista· 3 shared J. E. Manning Fox· 3 shared P. E. Macdonald· 3 shared A. F. Spigelman· 2 shared N. Smith· 2 shared R. Arrojo e Drigo· 2 shared T. dos Santos· 2 shared A. Alfirevic· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPhysiology

A. Bautista

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Complete Suspension Differentiation of Human Pluripotent Stem Cells into Pancreatic Islets Using Vertical-Wheel Bioreactors

N. Dadheech, M. Bermudez de Leon, N. Cuesta-Gomez, I. T. Jasra, R. Pawlick, B. Marfil-Garza, K. Verhoeff, S. Sapkota, H. Razavy, P. Anwar, J. Lyon, P. E. Macdonald, D. O' Gorman, G. Jickling, A. J. Shapiro

This study describes an all-stages complete suspension protocol for generating functional pancreatic islets from human pluripotent stem cells using Vertical Wheel bioreactors.

bioRxiv · Aug 9, 2023 · PreprintBioengineering

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study

A. L. Ball, C. E. Jolly, J. Lyon, A. Alfirevic, A. Chadwick

This study generates HepG2 transmitochondrial cybrids with mtDNA haplogroups H and J to assess their susceptibility to mitochondrial toxicants, finding haplogroup J shows greater sensitivity to certain drugs.

eLife · Jun 6, 2023Peer-reviewedPharmacology & Toxicology

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

T. J. Dafoe, T. dos Santos, A. F. Spigelman, J. Lyon, N. Smith, A. Bautista, P. E. MacDonald, J. E. Manning Fox

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

bioRxiv · Dec 24, 2021Physiology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

R. Arrojo e Drigo, G. Erikson, S. Tyagi, J. Capitanio, J. Lyon, A. Spigelman, A. Bautista, J. E. Manning Fox, M. Shokhirev, P. MacDonald, M. Hetzer

This study analyzes age-related changes in human endocrine pancreatic cell types, finding sex-specific and cell-type-specific effects of aging on beta cell function and transcriptional profiles.

bioRxiv · Aug 8, 2019 · PreprintPhysiology