Author

A. Alfirevic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:rat· 1

Frequent Co-Authors

A. Chadwick· 1 shared A. Jorgensen· 1 shared A. L. Ball· 1 shared C. E. Jolly· 1 shared D. Dickens· 1 shared H. R. Snodgrass· 1 shared J. Lyon· 1 shared M. A. Smith· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Chadwick

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Author profile →

2 papers

Recent·Most cited

Role of transporters and enzymes in metabolism and distribution of 4-chlorokynurenine and metabolites

W. Patel, R. G. Shankar, M. A. Smith, H. R. Snodgrass, M. Pirmohamed, A. Jorgensen, A. Alfirevic, D. Dickens

The paper investigates the metabolism and distribution of 4-chlorokynurenine and its metabolites, identifying a novel acetylated metabolite and pharmacogenetic associations affecting drug levels and transporter interactions.

bioRxiv · Jul 14, 2023 · PreprintPharmacology & Toxicology

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study

A. L. Ball, C. E. Jolly, J. Lyon, A. Alfirevic, A. Chadwick

This study generates HepG2 transmitochondrial cybrids with mtDNA haplogroups H and J to assess their susceptibility to mitochondrial toxicants, finding haplogroup J shows greater sensitivity to certain drugs.

eLife · Jun 6, 2023Peer-reviewedPharmacology & Toxicology