Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
D. A. Hofman, J. Ruiz-Orera, I. Yannuzzi, R. Murugesan, A. Brown, K. R. Clauser, A. L. Condurat, J. T. van Dinter, S. A. G. Engels, A. Goodale, J. van der Lugt, T. Abid, L. Wang, K. N. Zhou, J. Vogelzang, , J. R. Prensner
The paper investigates non-canonical ORF translation in medulloblastoma, identifying ASNSD1-uORF as critical for cell survival through interactions with the prefoldin-like chaperone complex.
bioRxiv · May 4, 2023Cancer Biology