Author

J. Ruiz-Orera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:Ribo-seq· 2

Frequent Co-Authors

M. M. Alba· 4 shared J. L. Villanueva-Canas· 3 shared X. Messeguer· 2 shared A. Brown· 1 shared A. Goodale· 1 shared A. L. Condurat· 1 shared B. Blasco-Moreno· 1 shared D. A. Hofman· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersEvolutionary Biology

M. M. Alba

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

D. A. Hofman, J. Ruiz-Orera, I. Yannuzzi, R. Murugesan, A. Brown, K. R. Clauser, A. L. Condurat, J. T. van Dinter, S. A. G. Engels, A. Goodale, J. van der Lugt, T. Abid, L. Wang, K. N. Zhou, J. Vogelzang, , J. R. Prensner

The paper investigates non-canonical ORF translation in medulloblastoma, identifying ASNSD1-uORF as critical for cell survival through interactions with the prefoldin-like chaperone complex.

bioRxiv · May 4, 2023Cancer Biology

Frequent birth of de novo genes in the compact yeast genome

W. R. Blevins, J. Ruiz-Orera, X. Messeguer, B. Blasco-Moreno, J. L. Villanueva-Canas, L. Espinar, J. Diez, L. Carey, M. M. Alba

This study identifies de novo genes in yeast genomes, showing they arise frequently despite compact genomes and some are translated and under selection.

bioRxiv · Mar 13, 2019 · PreprintEvolutionary Biology

Frequent translation of small open reading frames in evolutionary conserved lncRNA regions

J. Ruiz-Orera, M. M. Alba

The paper identifies translated open reading frames in conserved transcripts using ribosome profiling and finds they are enriched for functional micropeptides and non-ribosomal interactions.

bioRxiv · Jun 16, 2018Evolutionary Biology

Evidence for functional and non-functional classes of peptides translated from long non-coding RNAs

J. Ruiz-Orera, P. Verdaguer-Grau, J. L. Villanueva-Canas, X. Messeguer, M. M. Alba

The paper identifies prevalent peptides from mouse genes without rat/human homologues, suggesting they arise from neutral processes rather than functional necessity.

Nature Ecology & Evolution · Mar 19, 2018Peer-reviewedEvolutionary Biology

New genes and functional innovation in mammals

J. L. Villanueva-Canas, J. Ruiz-Orera, M. I. Agea, M. Gallo, D. Andreu, M. M. Alba

The paper identifies mammalian-specific gene families and finds that new genes often originate from non-coding regions and are expressed in testis, suggesting a role for sexual selection in their evolution.

bioRxiv · Jun 29, 2017Evolutionary Biology