Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
S. Weingarten-Gabbay, D.-Y. Chen, S. Sarkizova, H. B. Taylor, M. Gentili, L. R. Pearlman, M. R. Bauer, C. M. Rice, K. R. Clauser, N. Hacohen, S. A. Carr, J. G. Abelin, M. Saeed, P. C. Sabeti
The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.
bioRxiv · May 26, 2023Microbiology
D. A. Hofman, J. Ruiz-Orera, I. Yannuzzi, R. Murugesan, A. Brown, K. R. Clauser, A. L. Condurat, J. T. van Dinter, S. A. G. Engels, A. Goodale, J. van der Lugt, T. Abid, L. Wang, K. N. Zhou, J. Vogelzang, , J. R. Prensner
The paper investigates non-canonical ORF translation in medulloblastoma, identifying ASNSD1-uORF as critical for cell survival through interactions with the prefoldin-like chaperone complex.
bioRxiv · May 4, 2023Cancer Biology
K. Phulphagar, C. Ctortecka, S. Vaca, S. Klaeger, E. K. Verzani, G. M. Hernandez, N. Udeshi, K. R. Clauser, J. Abelin, S. A. Carr
This paper develops a high-throughput, sensitive MS-based immunopeptidomics workflow to identify HLA-I and HLA-II peptides from tumor samples, achieving improved coverage with reduced sample requirements.
bioRxiv · Mar 10, 2023Immunology
J. G. Abelin, E. J. Bergstrom, H. B. Taylor, K. D. Rivera, S. Klaeger, C. Xu, C. J. White, M. E. Olive, M. Maynard, M. H. Kane, S. Rachimi, D. R. Mani, M. A. Gillette, K. R. Clauser, N. D. Udeshi, S. A. Carr
MONTE enables serial multi-omic analysis of immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome from the same tissue samples, preserving precious human material and identifying immunotherapeutic targets.
bioRxiv · Jun 22, 2021 · PreprintCancer Biology
S. Klaeger, A. Apffel, K. R. Clauser, S. Sarkizova, G. Oliveira, S. Rachimi, P. M. Le, A. Tarren, V. Chea, J. G. Abelin, D. A. Braun, P. A. Ott, H. Keshishian, N. Hacohen, D. Keskin, , S. A. Carr
The paper improves HLA-peptidome coverage using optimized liquid and gas phase fractionation methods, enabling detection of more peptides from limited clinical tissue samples.
bioRxiv · May 25, 2021Biochemistry
S. Weingarten-Gabbay, S. Klaeger, S. Sarkizova, L. R. Pearlman, D.-Y. Chen, M. R. Bauer, H. B. Taylor, H. L. Conway, C. H. Tomkins-Tinch, Y. Finkel, A. Nachshon, M. Gentili, K. D. Rivera, D. B. Keskin, C. M. Rice, , P. C. Sabeti
The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.
bioRxiv · Oct 2, 2020 · PreprintImmunology
J. R. Prensner, O. M. Enache, V. Luria, K. Krug, K. R. Clauser, J. M. Dempster, A. Karger, L. Wang, K. Stumbraite, V. M. Wang, G. Botta, N. J. Lyons, A. Goodale, Z. Kalani, B. Fritchman, , T. R. Golub
The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.
bioRxiv · Mar 10, 2020 · PreprintCancer Biology
T. Ouspenskaia, T. Law, K. R. Clauser, S. Klaeger, S. Sarkizova, F. Aguet, B. Li, E. Christian, B. A. Knisbacher, P. M. Le, C. R. Hartigan, H. Keshishian, A. Apffel, G. Oliveira, W. Zhang, , A. Regev
The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.
bioRxiv · Feb 12, 2020 · PreprintCancer Biology