Author

J. R. Prensner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Brown· 2 shared A. Goodale· 2 shared D. E. Root· 2 shared J. A. Roth· 2 shared K. R. Clauser· 2 shared L. Wang· 2 shared T. R. Golub· 2 shared A. Karger· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

A. Brown

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2 papers

Recent·Most cited

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

D. A. Hofman, J. Ruiz-Orera, I. Yannuzzi, R. Murugesan, A. Brown, K. R. Clauser, A. L. Condurat, J. T. van Dinter, S. A. G. Engels, A. Goodale, J. van der Lugt, T. Abid, L. Wang, K. N. Zhou, J. Vogelzang, , J. R. Prensner

The paper investigates non-canonical ORF translation in medulloblastoma, identifying ASNSD1-uORF as critical for cell survival through interactions with the prefoldin-like chaperone complex.

bioRxiv · May 4, 2023Cancer Biology

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

J. R. Prensner, O. M. Enache, V. Luria, K. Krug, K. R. Clauser, J. M. Dempster, A. Karger, L. Wang, K. Stumbraite, V. M. Wang, G. Botta, N. J. Lyons, A. Goodale, Z. Kalani, B. Fritchman, , T. R. Golub

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology