NEDD8 activity is important for direct antigen MHC class I antigen presentation
K. Vijayasimha, A. L. Leestemaker-Palmer, J. S. Gibbs, J. W. Yewdell, B. P. Dolan
This study shows NEDD8 activity supports direct antigen presentation via proteasomal degradation of model antigens, but not by directly targeting proteins for degradation.
bioRxiv · Feb 25, 2022 · PreprintImmunology