J. W. Yewdell

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.

The paper identifies an 'alert-state' ribosome subpopulation (ASRs) that regulates cytokine-mediated processes by preferentially translating key mRNAs involved in immune responses.

This study shows that N proteins from SARS-CoV-2 and HCoV-OC43 are expressed on cell surfaces, modulating immune responses by binding chemokines and cytokines.

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

This study shows NEDD8 activity supports direct antigen presentation via proteasomal degradation of model antigens, but not by directly targeting proteins for degradation.

This study shows SARS-CoV-2 nucleocapsid protein binds to chemokines and modulates immune responses, suggesting it as a target for cross-reactive vaccines.

This paper develops a cell-based assay to measure SARS-CoV-2 Spike protein binding and infectivity across ACE2 orthologs by normalizing ACE2 expression levels using a reporter protein.

The paper analyzes single-cell BCR and transcriptome data from influenza-infected mice to reveal organ-specific B cell dynamics and clonal responses.

The paper uses synthetic mRNA libraries to study 5'UTR sequence elements affecting mRNA translatability and stability in mammalian cells, identifying regulatory features and decay pathways.

The paper identifies genes modulating MHC-I and MHC-II expression in lymphomas, revealing potential targets for immunosurveillance manipulation.

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.