A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor
A. Timon-Gomez, A. L. Scharr, N. Y. Wong, E. Ni, A. Roy, M. Liu, J. Chau, J. L. Lampert, H. Hireed, N. S. Kim, M. Jan, A. R. Gupta, R. W. Day, J. M. Gardner, R. J. Wilson, , A. J. Chang
This study identifies HIGD1C as a novel ETC Complex IV subunit in carotid body glomus cells that enhances hypoxia sensitivity, contributing to oxygen sensing and potential therapeutic targets for CB-related diseases.
bioRxiv · Oct 4, 2021 · PreprintPhysiology