J. M. Gardner

Nucleoside-driven specificity of DNA Methyltransferase

The paper studies the adenosine binding specificities of two bacterial DNA methyltransferases, showing differences in cofactor recognition and suggesting a new approach for designing unnatural cofactor analogs.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor

This study identifies HIGD1C as a novel ETC Complex IV subunit in carotid body glomus cells that enhances hypoxia sensitivity, contributing to oxygen sensing and potential therapeutic targets for CB-related diseases.

The effect of grape juice dilution on oenological fermentation

This study examines how diluting grape juice with water affects fermentation duration and outcomes in winemaking, finding that dilution shortens fermentation and alters volatile compound concentrations.

High-throughput identification of nuclear envelope protein interactions in Schizosaccharomyces pombe using an arrayed membrane yeast-two hybrid library

The paper develops a high-throughput method to identify nuclear envelope protein interactions in fission yeast using a membrane yeast-two hybrid system.

SWR1-independent association of H2A.Z to the LINC complex promotes meiotic chromosome motion

The paper shows H2A.Z, independent of SWR1, associates with the LINC complex at meiotic telomeres and centrosomes, promoting chromosome motion during meiosis.

Interpretable multimodal deep learning for real-time pan-tissue pan-disease pathology search on social media

The paper develops interpretable deep learning models to search for similar disease states across social media and PubMed using histopathology images and clinical data, achieving high precision in real-time diagnosis assistance.

Membrane insertion function for SUN-KASH complex revealed by high resolution analysis of yeast centrosomes

The paper uses high-resolution imaging to reveal the structure and function of the SUN-KASH complex in yeast centrosome insertion, identifying Mps3 as a fifth SPIN component and a novel LINC complex.