Author

A. Barrientos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Approach:statistical model· 3

Frequent Co-Authors

A. Amunts· 2 shared I. C. Soto· 2 shared J. C. Moran· 2 shared M. Couvillion· 2 shared V. Singh· 2 shared Y. Itoh· 2 shared A. Crocker· 1 shared A. Gokhale· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. Amunts

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome

H. Zhong, A. Janer, O. Khalimonchuk, H. Antonicka, E. Shoubridge, A. Barrientos

This study identifies BOLA3 and NFU1 as critical for mitoribosome iron-sulfur cluster assembly, linking their dysfunction to mitochondrial and metabolic disorders.

bioRxiv · May 27, 2023Biochemistry

Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications

V. Singh, Y. Itoh, S. Del'Olio, A. Hassan, A. Naschberger, R. K. Flygaard, Y. Nobe, K. Izumikawa, S. Aibara, J. Andrell, P. Whitford, A. Barrientos, M. Taoka, A. Amunts

The paper presents a high-resolution structure of the human mitoribosome, revealing mechanisms of mRNA binding, tRNA interactions, and roles of cofactors and rRNA modifications.

bioRxiv · May 24, 2023 · PreprintBiochemistry

Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome

V. Singh, J. C. Moran, Y. Itoh, I. C. Soto, F. Fontanesi, M. Couvillion, M. Huynen, S. Churchman, A. Barrientos, A. Amunts

The paper determines the cryo-EM structure of LRPPRC-SLIRP complex with mRNA and mitoribosome, showing its role in mRNA delivery and translation regulation.

bioRxiv · Jun 20, 2022Biochemistry

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

M. E. Wynne, O. Ogunbona, A. R. Lane, A. Gokhale, S. A. Zlatic, C. Xu, Z. Wen, D. Duong, S. Rayaprolu, A. Ivanova, E. A. Ortlund, E. B. Dammer, N. T. Seyfried, B. R. Roberts, A. Crocker, , V. Faundez

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

bioRxiv · May 11, 2022Cell Biology

A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor

A. Timon-Gomez, A. L. Scharr, N. Y. Wong, E. Ni, A. Roy, M. Liu, J. Chau, J. L. Lampert, H. Hireed, N. S. Kim, M. Jan, A. R. Gupta, R. W. Day, J. M. Gardner, R. J. Wilson, , A. J. Chang

This study identifies HIGD1C as a novel ETC Complex IV subunit in carotid body glomus cells that enhances hypoxia sensitivity, contributing to oxygen sensing and potential therapeutic targets for CB-related diseases.

bioRxiv · Oct 4, 2021 · PreprintPhysiology

Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes

I. C. Soto, M. Couvillion, E. McShane, K. G. Hansen, J. C. Moran, A. Barrientos, L. S. Churchman

The paper investigates how human cells balance mitochondrial and cytosolic translatomes to coordinate OXPHOS complex biogenesis and maintains proteostasis through LRPPRC.

bioRxiv · May 31, 2021Cell Biology