Thienothiazolocarboxamides: rapidly cidal agents causing catastrophic thiol collapse in Mycobacterium tuberculosis.
S. Oh, G. Prosser, H. I. M. Boshoff, S. R. Green, N. Quadir, J. S. O. Roma, A. Kumar, N. Mukundan, S. Hanson, J. P. Sarathy, K. I. Buchanan, P. C. Ray, P. G. Wyatt, T. R. Ioerger, A. L. Schwan, , C. E. Barry
This paper identifies thienothiazolocarboxamides as rapidly cidal antituberculosis agents that cause thiol collapse in Mycobacterium tuberculosis through EthA-mediated activation.
bioRxiv · Nov 9, 2026 · PreprintMicrobiology