T. R. Ioerger

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113

This study identifies callyaerins as antitubercular agents targeting the M. tuberculosis-specific protein Rv2113, showing efficacy against drug-resistant strains with minimal cytotoxicity.

Functional whole genome screen of nutrient-starved Mycobacterium tuberculosis identifies genes involved in antibiotic tolerance

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains

This study uses transposon-sequencing to analyze functional genomic diversity across 21 Mycobacterium abscessus isolates, identifying essential and non-essential genes and previously uncharacterized genetic networks.

Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex

The paper identifies phase variation in Mycobacterium tuberculosis complex as an adaptive mechanism, showing it alters gene expression and virulence.

Drosophila melanogaster is a powerful host model to study mycobacterial virulence

This study uses Drosophila to identify mycobacterial virulence factors, finding conserved mechanisms between Mmar and Mtb.

Multiplexed strain phenotyping defines consequences of genetic diversity in Mycobacterium tuberculosis for infection and vaccination outcomes

This study uses molecular barcoding to analyze genetic diversity in Mtb strains, showing L2 strains have distinct growth dynamics and resist BCG vaccination.

High-density transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivity

Modeling site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets

This paper identifies site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets and introduces a new method to improve the identification of conditionally essential genes.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality

The paper builds MtbTnDB, a database of Mtb TnSeq screens, enabling comparison of genetic essentiality across conditions and analysis of gene function.

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

Cell cycle-associated expression patterns predict gene function in mycobacteria

The paper identifies cell cycle-associated gene expression patterns in Mycobacterium tuberculosis and links them to specific biological functions.

A conserved translation factor is required for optimal synthesis of a membrane protein family in mycobacteria

This study identifies LepA as a conserved GTPase that enhances the synthesis of mycobacterial porins, affecting drug tolerance and membrane permeability.

Global assessment of Mycobacterium avium subspecies hominissuis genetic requirement for growth and virulence.

This study identifies genetic requirements for growth and virulence in Mycobacterium avium subsp. hominissuis using transposon mutagenesis, revealing shared and unique genes with M. tuberculosis.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

Genetic variation/evolution and differential host responses resulting from in-patient adaptation of Mycobacterium avium

This study examines genetic changes in Mycobacterium avium isolates from infected patients over time and links these changes to altered host immune responses and increased bacterial persistence.

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.