Author

H. I. M. Boshoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:bacteria (other)· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. G. Coyne· 2 shared C. Abell· 2 shared C. E. Barry· 2 shared T. L. Blundell· 2 shared V. Mendes· 2 shared V. Mizrahi· 2 shared A. Borsellini· 1 shared A. J. Whitehouse· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. G. Coyne

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivOct 27, 2021

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini…·V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

DOI 10.1021/acsinfecdis.1c00643

bacteria (other)experimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintJan 15, 2020

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site.

V. Mendes, S. R. Green, J. C. Evans…·T. L. Blundell

The paper identifies potent inhibitors of Mycobacterium tuberculosis CoaB by targeting a novel allosteric site, based on structural and biochemical analyses of CoaBC.

DOI 10.1101/870154

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivMay 19, 2019

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

S. E. Thomas, A. J. Whitehouse, K. Brown…·V. Mendes

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

DOI 10.1093/nar/gkaa539

humanproteomics

𝕏 PostBluesky