The protein phosphatase-2A subunit PR130 is linked to cytotoxic protein aggregate formation in mesenchymal pancreatic ductal adenocarcinoma cells
O. H. Kramer, A. Nguyen, A. Leydecker, A.-H. M. Mustafa, J. Murr, F. Butter
This study shows that mesenchymal pancreatic ductal adenocarcinoma cells depend on the PP2A subunit PR130, and its inhibition by phendione leads to apoptosis and protein aggregate formation.
bioRxiv · Sep 3, 2023 · PreprintCancer Biology