Author

O. H. Kramer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1

Frequent Co-Authors

A.-H. M. Mustafa· 2 shared A. Baluapuri· 1 shared A. G. Kansy· 1 shared A. Illendula· 1 shared A. Leydecker· 1 shared A. Nguyen· 1 shared A. Piee-Staffa· 1 shared A. T. den Dekker· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A.-H. M. Mustafa

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Author profile →

3 papers

Recent·Most cited

The protein phosphatase-2A subunit PR130 is linked to cytotoxic protein aggregate formation in mesenchymal pancreatic ductal adenocarcinoma cells

O. H. Kramer, A. Nguyen, A. Leydecker, A.-H. M. Mustafa, J. Murr, F. Butter

This study shows that mesenchymal pancreatic ductal adenocarcinoma cells depend on the PP2A subunit PR130, and its inhibition by phendione leads to apoptosis and protein aggregate formation.

bioRxiv · Sep 3, 2023 · PreprintCancer Biology

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

M. A. Fischer, A.-H. M. Mustafa, K. Hausmann, R. Ashry, A. G. Kansy, M. C. Liebl, C. Brachetti, A. Piee-Staffa, M. Zessin, H. S. Ibrahim, T. G. Hofmann, M. Schutkowski, W. Sippl, O. H. Kramer

This paper synthesizes novel HDAC inhibitors that show nanomolar activity against class I HDACs and induce apoptosis while constraining autophagy in leukemic cells.

bioRxiv · Mar 9, 2023Pharmacology & Toxicology

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

J. Doffo, S. A. Bamopoulos, H. Kose, F. Orben, M. Pons, A. T. den Dekker, R. W. W. Brouwer, A. Baluapuri, S. Habringer, M. Reichert, A. Illendula, O. H. Kramer, M. Schick, E. Wolf, W. F. J. van IJcken, , M. Wirth

The paper identifies RUNX1 inhibition as a strategy to induce NOXA-dependent apoptosis in pancreatic cancer, showing it blocks tumor growth in vivo and in organoids.

bioRxiv · Oct 21, 2021Cancer Biology