Polyvalent Guide RNAs for CRISPR Antivirals
R. Bagchi, R. Tinker-Kulberg, T. Supakar, S. Chamberlain, A. Ligaba-Osena, E. A. Josephs
This paper designs polyvalent guide RNAs (pgRNAs) for CRISPR antivirals that can target multiple viral sites simultaneously, showing improved suppression of plant RNA viruses compared to monovalent gRNAs.
bioRxiv · Feb 25, 2021Bioengineering