A. Loiselle

Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

This study shows that inhibiting S100a4 improves tendon healing by reducing scar formation and enhancing mechanical properties through cell non-autonomous mechanisms.

Scleraxis Lineage Cells Contribute to Organized Bridging Tissue During Tendon Healing, and Identifies Subpopulations of Resident Tendon Cells

This study shows Scleraxis lineage cells form an organized bridge during tendon healing and identify distinct subpopulations of tendon cells.

Non-invasive ultrasound quantification of Scar Tissue Volume predicts functional changes during tendon healing

This study quantifies scar tissue volume via ultrasound to predict functional changes during tendon healing and identifies its utility in screening therapeutic interventions.

Insulin Receptor Deletion in S100a4-lineage cells accelerates age-related bone loss

This study deletes the insulin receptor in S100a4-lineage cells in mice and finds accelerated age-related bone loss in older adults.

Obesity/Type II Diabetes Promotes Function-Limiting Changes In Flexor Tendon Extracellular Matrix Organization That Are Not Reversed By Restoring Normal Metabolic Function

This study develops a murine model of diabetic tendinopathy and shows that restoring normal metabolic function does not reverse tendon impairments caused by obesity/T2DM.

Deletion Of EP4 In S100a4-Lineage Cells Reduces Scar Tissue Formation During Early But Not Later Stages Of Tendon Healing

This study shows that deleting EP4 in S100a4-lineage cells reduces scar tissue formation early in tendon healing but not later, with increased EP4-expressing myofibroblasts contributing to impaired gliding function later.

Obesity/Type II Diabetes Alters Macrophage Polarization Resulting in a Fibrotic Tendon Healing Response

This study shows that obesity and T2DM lead to increased scar formation and fibrotic healing in tendons through enhanced M2 macrophage polarization and matrix synthesis.