Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells
J. He, A. M. Abikoye, B. P. McLaughlin, R. S. Middleton, R. Sheldon, R. G. Jones, Z. T. Schafer
This study shows ECM-detached cancer cells resist ferroptosis due to reduced free iron levels from altered iron metabolism, suggesting potential limitations for ferroptosis-based therapies.
bioRxiv · Sep 23, 2022Cell Biology