Z. T. Schafer

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells

This study shows that senescent fibroblast-secreted factors induce pyroptotic cell death in mammary epithelial cells, independent of oncogenic signaling.

Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells

This study shows ECM-detached cancer cells resist ferroptosis due to reduced free iron levels from altered iron metabolism, suggesting potential limitations for ferroptosis-based therapies.

Oncogenic signaling inhibits c-FLIP expression and promotes cancer cell survival during ECM-detachment

SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells

This study shows SGK1 promotes glucose metabolism and cell survival in ECM-detached cells by enhancing glucose uptake and PPP flux for ATP production.