R. G. Jones

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

Quantitative Analysis of Autophagy in Single Cells: Differential Response to Amino Acid and Glucose Starvation

This study quantifies autophagy responses in single U2OS cells to amino acid and glucose starvation, finding that amino acid starvation induces autophagy while glucose starvation does not.

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8+ T cells

This study uses 13C-labeled metabolites to show CD8+ T cells switch from glutamine to acetate metabolism during infection.

An acute microglial metabolic response controls metabolism and improves memory

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells

This study shows ECM-detached cancer cells resist ferroptosis due to reduced free iron levels from altered iron metabolism, suggesting potential limitations for ferroptosis-based therapies.

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.

This study identifies a non-canonical role for GAD1 in cancer cell amino acid homeostasis, independent of the GABA shunt, by regulating amino acid transporter expression.

Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment

The paper shows that miR-17~92 expression in Myc+ tumors increases sensitivity to biguanide treatment by disrupting bioenergetic stability in lymphoma cells.