Cancer BiologybioRxiv
Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents
W. Wang, M. Rodriguez-Silva, A. M. Acanda de la Rocha…·Y.-C. Tse-Dinh
This study identifies the TDP1/TOP1 activity ratio as a predictive indicator for GBM susceptibility to irinotecan, suggesting TDP1 inhibition could enhance treatment efficacy.
DOI 10.3390/cancers11101416