Author

Y.-C. Tse-Dinh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Assay:DNA methylation· 1 Organism:E. coli· 1 Assay:proteomics· 1

Frequent Co-Authors

W. Wang· 2 shared Y. Pommier· 2 shared A. L. Wolf· 1 shared A. M. Acanda de la Rocha· 1 shared A. Seddek· 1 shared A.-C. Uhlemann· 1 shared D. Le· 1 shared D. Sun· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

W. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Topoisomerase 3B (TOP3B) DNA and RNA Cleavage Complexes and Pathway to Repair TOP3B-linked RNA and DNA Breaks

S. Saha, S.-Y. Huang, U. Jo, H. Zhang, Y.-C. Tse-Dinh, Y. Pommier

The paper identifies a pathway for repairing TOP3B DNA and RNA cleavage complexes, showing that TDP2 excises ubiquitinated TOP3Bccs after proteasomal degradation.

bioRxiv · Mar 22, 2020Cell Biology

Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents

W. Wang, M. Rodriguez-Silva, A. M. Acanda de la Rocha, A. L. Wolf, Y. Lai, Y. Liu, W. C. Reinhold, Y. Pommier, J. W. Chambers, Y.-C. Tse-Dinh

This study identifies the TDP1/TOP1 activity ratio as a predictive indicator for GBM susceptibility to irinotecan, suggesting TDP1 inhibition could enhance treatment efficacy.

bioRxiv · Jul 14, 2019Cancer Biology

Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

P. K. Garcia, T. Annamalai, W. Wang, R. S. Bell, D. Le, P. Martin Pancorbo, S. Sikandar, A. Seddek, X. Yu, D. Sun, A.-C. Uhlemann, P. B. Tiwari, F. Leng, Y.-C. Tse-Dinh

This study investigates the antimycobacterial mechanism of FP-11g, a fluoroquinophenoxazine compound, and identifies resistance mechanisms in Mycobacterium smegmatis.

bioRxiv · Nov 7, 2018Microbiology

Direct Observation of Topoisomerase IA Gate Dynamics

M. Mills, Y.-C. Tse-Dinh, K. C. Neuman

This study directly observes the gate dynamics of E. coli type IA topoisomerases I and III using a single-molecule assay, revealing gate opening and force resistance.

bioRxiv · Jul 20, 2018Biophysics