Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice
A. M. Bobe, J. Miyoshi, P. Moore, S. Devkota, V. Leone, K. Martinez, B. R. Theriault, M. W. Musch, C. Wasserfall, M. Atkinson, C. J. Rhodes, E. B. Chang
This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.
bioRxiv · Apr 18, 2020 · PreprintPhysiology