C. J. Rhodes

Enrichment of Cysteine S-palmitoylation using Sodium Deoxycholate Acid Precipitation - SDC-ACE

The paper introduces SDC-ACE, a method to enrich S-palmitoylated peptides, and applies it to study S-palmitoylation in mouse brain and tissues, revealing its role in diabetes and obesity.

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

PTPN1 deficiency modulates BMPR2 signaling and induces endothelial dysfunction in Pulmonary Arterial Hypertension

This study identifies PTPN1 as a regulator of BMPR2 signaling in PAH, showing its downregulation in PAH patients and link to endothelial dysfunction.

Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

This study identifies RGMB-AS1 as an upregulated lncRNA in PAH that modulates BMPR2 signaling and improves vascular cell function when inhibited.

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice

This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.