J. Miyoshi

Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

The paper shows fast-food diets cause gut microbiota imbalances that predict and drive NAFLD progression in mice, with effects seen in conventionally-raised but not germ-free mice.

Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism

This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine model

The paper examines gut microbiota metagenomic profiles in a murine model to predict colitis onset and finds functional subsystems, particularly nitrogen metabolism, differ between mice that develop colitis and those that do not.

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice

This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.

Understanding artificial mouse-microbiome heterogeneity and six actionable themes to increase study power

The paper identifies six actionable themes to reduce artificial heterogeneity in mouse-microbiome studies by addressing statistical and practical issues in housing density and data analysis.